Deep learning model enables the discovery of a novel immunotherapeutic agent regulating the kynurenine pathway

Kynurenine (Kyn) is a key inducer of an immunosuppressive tumor microenvironment (TME). Although indoleamine 2,3-dioxygenase (IDO)-selective inhibitors have been developed to suppress the Kyn pathway, the results were not satisfactory due to the presence of various opposing mechanisms. Here, we empl...

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Detalles Bibliográficos
Autores principales: Kim, Jeong Hun, Lee, Won Suk, Lee, Hye Jin, Yang, Hannah, Lee, Seung Joon, Kong, so Jung, Je, Soyeon, Yang, Hyun-Jin, Jung, Jongsun, Cheon, Jaekyung, Kang, Beodeul, Chon, Hong Jae, Kim, Chan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632076/
https://www.ncbi.nlm.nih.gov/pubmed/34858729
http://dx.doi.org/10.1080/2162402X.2021.2005280

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632076/
https://www.ncbi.nlm.nih.gov/pubmed/34858729
http://dx.doi.org/10.1080/2162402X.2021.2005280

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