C9orf72 ALS-FTD: recent evidence for dysregulation of the autophagy-lysosome pathway at multiple levels

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two clinically distinct classes of neurodegenerative disorders. Yet, they share a range of genetic, cellular, and molecular features. Hexanucleotide repeat expansions (HREs) in the C9orf72 gene and the accumulation of toxic pr...

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Detalles Bibliográficos
Autores principales: Beckers, Jimmy, Tharkeshwar, Arun Kumar, Van Damme, Philip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632097/
https://www.ncbi.nlm.nih.gov/pubmed/33632058
http://dx.doi.org/10.1080/15548627.2021.1872189

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632097/
https://www.ncbi.nlm.nih.gov/pubmed/33632058
http://dx.doi.org/10.1080/15548627.2021.1872189

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