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The Versatile Gasdermin Family: Their Function and Roles in Diseases

The gasdermin (GSDM) family, a novel group of structure-related proteins, consists of GSDMA, GSDMB, GSDMC, GSDMD, GSDME/DNFA5, and PVJK/GSDMF. GSDMs possess a C-terminal repressor domain, cytotoxic N-terminal domain, and flexible linker domain (except for GSDMF). The GSDM-NT domain can be cleaved an...

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Detalles Bibliográficos
Autores principales: Zou, Ju, Zheng, Yixiang, Huang, Yan, Tang, Daolin, Kang, Rui, Chen, Ruochan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632255/
https://www.ncbi.nlm.nih.gov/pubmed/34858408
http://dx.doi.org/10.3389/fimmu.2021.751533