Cancer cells under immune attack acquire CD47-mediated adaptive immune resistance independent of the myeloid CD47-SIRPα axis

Cancer cells exploit CD47 overexpression to inhibit phagocytic elimination and neoantigen processing via the myeloid CD47-SIRPα axis and thereby indirectly evade adaptive T cell immunity. Here, we report on a hitherto unrecognized direct immunoinhibitory feature of cancer cell-expressed CD47. We unc...

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Detalles Bibliográficos
Autores principales: Hendriks, Mark A.J.M., Britsch, Isabel, Ke, Xiurong, van Wijngarden, Anne P., Samplonius, Douwe F., Ploeg, Emily M., Helfrich, Wijnand
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632294/
https://www.ncbi.nlm.nih.gov/pubmed/34858730
http://dx.doi.org/10.1080/2162402X.2021.2005344

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632294/
https://www.ncbi.nlm.nih.gov/pubmed/34858730
http://dx.doi.org/10.1080/2162402X.2021.2005344

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