Epigenetic condensates regulate chromatin activity and tumorigenesis

Alterations of epigenetic modulators are extensively associated with cancer, but their key molecular activities in cancer regulation are often unclear. We discovered that lysine demethylase 6A (KDM6A, also known as UTX) suppresses cancer by forming liquid-like condensates with lysine methyltransfera...

Descripción completa

Detalles Bibliográficos
Autores principales: Shi, Bi, Li, Wei, Jiang, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Author’s Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632315/
https://www.ncbi.nlm.nih.gov/pubmed/34859151
http://dx.doi.org/10.1080/23723556.2021.1997040
_version_ 1784607732767129600
author Shi, Bi
Li, Wei
Jiang, Hao
author_facet Shi, Bi
Li, Wei
Jiang, Hao
author_sort Shi, Bi
collection PubMed
description Alterations of epigenetic modulators are extensively associated with cancer, but their key molecular activities in cancer regulation are often unclear. We discovered that lysine demethylase 6A (KDM6A, also known as UTX) suppresses cancer by forming liquid-like condensates with lysine methyltransferase 2D (KMT2D, also known as MLL4) and regulating chromatin activity at multiple levels.
format Online
Article
Text
id pubmed-8632315
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Taylor & Francis
record_format MEDLINE/PubMed
spelling pubmed-86323152021-12-01 Epigenetic condensates regulate chromatin activity and tumorigenesis Shi, Bi Li, Wei Jiang, Hao Mol Cell Oncol Author’s Views Alterations of epigenetic modulators are extensively associated with cancer, but their key molecular activities in cancer regulation are often unclear. We discovered that lysine demethylase 6A (KDM6A, also known as UTX) suppresses cancer by forming liquid-like condensates with lysine methyltransferase 2D (KMT2D, also known as MLL4) and regulating chromatin activity at multiple levels. Taylor & Francis 2021-11-09 /pmc/articles/PMC8632315/ /pubmed/34859151 http://dx.doi.org/10.1080/23723556.2021.1997040 Text en © 2021 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author’s Views
Shi, Bi
Li, Wei
Jiang, Hao
Epigenetic condensates regulate chromatin activity and tumorigenesis
title Epigenetic condensates regulate chromatin activity and tumorigenesis
title_full Epigenetic condensates regulate chromatin activity and tumorigenesis
title_fullStr Epigenetic condensates regulate chromatin activity and tumorigenesis
title_full_unstemmed Epigenetic condensates regulate chromatin activity and tumorigenesis
title_short Epigenetic condensates regulate chromatin activity and tumorigenesis
title_sort epigenetic condensates regulate chromatin activity and tumorigenesis
topic Author’s Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632315/
https://www.ncbi.nlm.nih.gov/pubmed/34859151
http://dx.doi.org/10.1080/23723556.2021.1997040
work_keys_str_mv AT shibi epigeneticcondensatesregulatechromatinactivityandtumorigenesis
AT liwei epigeneticcondensatesregulatechromatinactivityandtumorigenesis
AT jianghao epigeneticcondensatesregulatechromatinactivityandtumorigenesis

Ejemplares similares