Chromatin state profiling reveals PRC2 inhibition as a therapeutic target in NRAS–mutant melanoma

Recently, we have generated 284 epigenomic maps in melanoma. Using chromatin state profiling we identify an association of NRAS-mutants with bivalent Histone H3 lysine 27 trimethylation (H3K27me3) and broad H3K4me3 domains. Reprogramming of bivalent H3K27me3 occurs on critical invasive-regulators an...

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Detalles Bibliográficos
Autor principal: Terranova, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632323/
https://www.ncbi.nlm.nih.gov/pubmed/34859147
http://dx.doi.org/10.1080/23723556.2021.1986350

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632323/
https://www.ncbi.nlm.nih.gov/pubmed/34859147
http://dx.doi.org/10.1080/23723556.2021.1986350

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