Base-edited CAR T cells for combinational therapy against T cell malignancies

Targeting T cell malignancies using chimeric antigen receptor (CAR) T cells is hindered by ‘T v T’ fratricide against shared antigens such as CD3 and CD7. Base editing offers the possibility of seamless disruption of gene expression of problematic antigens through creation of stop codons or eliminat...

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Detalles Bibliográficos
Autores principales: Georgiadis, Christos, Rasaiyaah, Jane, Gkazi, Soragia Athina, Preece, Roland, Etuk, Aniekan, Christi, Abraham, Qasim, Waseem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632682/
https://www.ncbi.nlm.nih.gov/pubmed/34035409
http://dx.doi.org/10.1038/s41375-021-01282-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632682/
https://www.ncbi.nlm.nih.gov/pubmed/34035409
http://dx.doi.org/10.1038/s41375-021-01282-6

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