STAT3 activation in large granular lymphocyte leukemia is associated with cytokine signaling and DNA hypermethylation

Large granular lymphocyte leukemia (LGLL) is characterized by somatic gain-of-function STAT3 mutations. However, the functional effects of STAT3 mutations on primary LGLL cells have not been studied in detail. In this study, we show that CD8+ T cells isolated from STAT3 mutated LGLL patients have hi...

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Detalles Bibliográficos
Autores principales: Kim, Daehong, Park, Giljun, Huuhtanen, Jani, Ghimire, Bishwa, Rajala, Hanna, Moriggl, Richard, Chan, Wing C., Kankainen, Matti, Myllymäki, Mikko, Mustjoki, Satu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632689/
https://www.ncbi.nlm.nih.gov/pubmed/34075200
http://dx.doi.org/10.1038/s41375-021-01296-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632689/
https://www.ncbi.nlm.nih.gov/pubmed/34075200
http://dx.doi.org/10.1038/s41375-021-01296-0

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