Discriminating between competing models for the allosteric regulation of oncogenic phosphatase SHP2 by characterizing its active state

The Src-homology 2 domain containing phosphatase 2 (SHP2) plays a critical role in crucial signaling pathways and is involved in oncogenesis and in developmental disorders. Its structure includes two SH2 domains (N-SH2 and C-SH2), and a protein tyrosine phosphatase (PTP) domain. Under basal conditio...

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Detalles Bibliográficos
Autores principales: Calligari, Paolo, Santucci, Valerio, Stella, Lorenzo, Bocchinfuso, Gianfranco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632847/
https://www.ncbi.nlm.nih.gov/pubmed/34900129
http://dx.doi.org/10.1016/j.csbj.2021.10.041

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632847/
https://www.ncbi.nlm.nih.gov/pubmed/34900129
http://dx.doi.org/10.1016/j.csbj.2021.10.041

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