Critical role of backbone coordination in the mRNA recognition by RNA induced silencing complex

Despite its functional importance, the molecular mechanism underlying target mRNA recognition by Argonaute (Ago) remains largely elusive. Based on extensive all-atom molecular dynamics simulations, we constructed quasi-Markov State Model (qMSM) to reveal the dynamics during recognition at position 6...

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Detalles Bibliográficos
Autores principales: Zhu, Lizhe, Jiang, Hanlun, Cao, Siqin, Unarta, Ilona Christy, Gao, Xin, Huang, Xuhui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632932/
https://www.ncbi.nlm.nih.gov/pubmed/34848812
http://dx.doi.org/10.1038/s42003-021-02822-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632932/
https://www.ncbi.nlm.nih.gov/pubmed/34848812
http://dx.doi.org/10.1038/s42003-021-02822-7

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