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Chronic cortisol differentially impacts stem cell-derived astrocytes from major depressive disorder patients

Major depressive disorder (MDD) is a prevalent psychiatric disorder, and exposure to stress is a robust risk factor for MDD. Clinical data and rodent models have indicated the negative impact of chronic exposure to stress-induced hormones like cortisol on brain volume, memory, and cell metabolism. H...

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Detalles Bibliográficos
Autores principales: Heard, Kelly J., Shokhirev, Maxim N., Becronis, Caroline, Fredlender, Callie, Zahid, Nadia, Le, Amy T., Ji, Yuan, Skime, Michelle, Nelson, Timothy, Hall-Flavin, Daniel, Weinshilboum, Richard, Gage, Fred H., Vadodaria, Krishna C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632962/
https://www.ncbi.nlm.nih.gov/pubmed/34848679
http://dx.doi.org/10.1038/s41398-021-01733-9