Loss of PRC2 subunits primes lineage choice during exit of pluripotency

Polycomb Repressive Complex 2 (PRC2) is crucial for the coordinated expression of genes during early embryonic development, catalyzing histone H3 lysine 27 trimethylation. Two distinct PRC2 complexes, PRC2.1 and PRC2.2, contain respectively MTF2 and JARID2 in embryonic stem cells (ESCs). In this stu...

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Detalles Bibliográficos
Autores principales: Loh, Chet H., van Genesen, Siebe, Perino, Matteo, Bark, Magnus R., Veenstra, Gert Jan C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632979/
https://www.ncbi.nlm.nih.gov/pubmed/34848733
http://dx.doi.org/10.1038/s41467-021-27314-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632979/
https://www.ncbi.nlm.nih.gov/pubmed/34848733
http://dx.doi.org/10.1038/s41467-021-27314-4

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