TIFAB accelerates MLL-AF9−Induced acute myeloid leukemia through upregulation of HOXA9

We previously showed stabilization of NIK−induced activation of NF-κB non-canonical signaling suppresses MLL-AF9−induced AML. In the current study, we demonstrate that deletion of NF-κB non-canonical RelB prevents the inhibitory effect of NIK stabilization in MLL-AF9 AML. Mechanistically, RelB suppr...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhao, Jinming, Xiu, Yan, Fu, Lin, Dong, Qianze, Borcherding, Nicholas, Wang, Yang, Li, Qingchang, De Silva, Nilushi S., Klein, Ulf, Boyce, Brendan F., Zhao, Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8633042/
https://www.ncbi.nlm.nih.gov/pubmed/34877491
http://dx.doi.org/10.1016/j.isci.2021.103425

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8633042/
https://www.ncbi.nlm.nih.gov/pubmed/34877491
http://dx.doi.org/10.1016/j.isci.2021.103425

Ejemplares similares