Cargando…

TIFAB accelerates MLL-AF9−Induced acute myeloid leukemia through upregulation of HOXA9

We previously showed stabilization of NIK−induced activation of NF-κB non-canonical signaling suppresses MLL-AF9−induced AML. In the current study, we demonstrate that deletion of NF-κB non-canonical RelB prevents the inhibitory effect of NIK stabilization in MLL-AF9 AML. Mechanistically, RelB suppr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhao, Jinming, Xiu, Yan, Fu, Lin, Dong, Qianze, Borcherding, Nicholas, Wang, Yang, Li, Qingchang, De Silva, Nilushi S., Klein, Ulf, Boyce, Brendan F., Zhao, Chen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8633042/ https://www.ncbi.nlm.nih.gov/pubmed/34877491 http://dx.doi.org/10.1016/j.isci.2021.103425

Ejemplares similares

Stabilization of NF-κB-Inducing Kinase Suppresses MLL-AF9-Induced Acute Myeloid Leukemia
por: Xiu, Yan, et al.
Publicado: (2018)

MLL-AF9 initiates transformation from fast-proliferating myeloid progenitors
por: Chen, Xinyue, et al.
Publicado: (2019)

314. Using CRISPR/Cas9 to dissect the regions of MLL/AF9 that are critical for myeloid immortalization
por: Yvanovich, Emma, et al.
Publicado: (2023)

CRISPR Gene Editing of Murine Blood Stem and Progenitor Cells Induces MLL-AF9 Chromosomal Translocation and MLL-AF9 Leukaemogenesis
por: Sarrou, Evgenia, et al.
Publicado: (2020)

P2X7 promotes the progression of MLL-AF9-induced acute myeloid leukemia by upregulation of Pbx3
por: Feng, Wenli, et al.
Publicado: (2020)

Publisher Correction: MLL-AF9 initiates transformation from fast-proliferating myeloid progenitors
por: Chen, Xinyue, et al.
Publicado: (2020)

HOXA9/IRX1 expression pattern defines two subgroups of infant MLL-AF4-driven acute lymphoblastic leukemia
por: Symeonidou, Vasiliki, et al.
Publicado: (2021)

The mechanism of MYB transcriptional regulation by MLL-AF9 oncoprotein
por: Cao, Lu, et al.
Publicado: (2019)

Protocol to establish a stable MLL-AF9_AML mouse model
por: Lu, Jun, et al.
Publicado: (2022)

SUV39H1 regulates the progression of MLL-AF9-induced acute myeloid leukemia
por: Chu, Yajing, et al.
Publicado: (2020)

Role of the bone marrow vascular niche in chemotherapy for MLL-AF9-induced acute myeloid leukemia
por: Xu, Chang, et al.
Publicado: (2023)

Human MLL-AF9 Overexpression Induces Aberrant Hematopoietic Expansion in Zebrafish
por: Tan, Jiaqi, et al.
Publicado: (2018)

MLL-AF9 and MLL-AF4 oncofusion proteins bind a distinct enhancer repertoire and target the RUNX1 program in 11q23 acute myeloid leukemia
por: Prange, K H M, et al.
Publicado: (2017)

Reprogramming of MLL-AF9 leukemia cells into pluripotent stem cells
por: Liu, Y, et al.
Publicado: (2014)

Nuclear FGFR2 Interacts with the MLL-AF4 Oncogenic Chimera and Positively Regulates HOXA9 Gene Expression in t(4;11) Leukemia Cells
por: Fioretti, Tiziana, et al.
Publicado: (2021)

Systematic characterization of the HOXA9 downstream targets in MLL-r leukemia by noncoding CRISPR screens
por: Wright, Shaela, et al.
Publicado: (2023)

Corrigendum to “Human MLL-AF9 Overexpression Induces Aberrant Hematopoietic Expansion in Zebrafish”
por: Tan, Jiaqi, et al.
Publicado: (2022)

Atg5-dependent autophagy contributes to the development of acute myeloid leukemia in an MLL-AF9-driven mouse model
por: Liu, Qiang, et al.
Publicado: (2016)

Integrated transcriptomic and epigenetic data analysis identifiesaberrant expression of genes in acute myeloid leukemia with MLL-AF9 translocation
por: Wang, Fangce, et al.
Publicado: (2020)

High Metabolic Dependence on Oxidative Phosphorylation Drives Sensitivity to Metformin Treatment in MLL/AF9 Acute Myeloid Leukemia
por: Liu, Longlong, et al.
Publicado: (2022)

Hoxa11-mediated reduction of cell migration contributes to myeloid sarcoma formation induced by cooperation of MLL/AF10 with activating KRAS mutation in a mouse transplantation model: Hoxa11 in myeloid sarcoma formation
por: Fu, Jen-Fen, et al.
Publicado: (2022)

Zoledronic acid inhibits the growth of leukemic MLL-AF9 transformed hematopoietic cells
por: Chiarella, Emanuela, et al.
Publicado: (2020)

Elucidating the Importance of DOT1L Recruitment in MLL-AF9 Leukemia and Hematopoiesis
por: Grigsby, Sierrah M., et al.
Publicado: (2021)

Peritoneal resident macrophages in mice with MLL-AF9-induced acute myeloid leukemia show an M2-like phenotype
por: Chen, Chong, et al.
Publicado: (2021)

Integrated transcriptomic and epigenetic data analysis identifies aberrant expression of genes in acute myeloid leukemia with MLL-AF9 translocation
por: Wang, Fangce, et al.
Publicado: (2021)

Regulation of CDX4 gene transcription by HoxA9, HoxA10, the Mll-Ell oncogene and Shp2 during leukemogenesis
por: Bei, L, et al.
Publicado: (2014)

Rheb1 promotes tumor progression through mTORC1 in MLL-AF9-initiated murine acute myeloid leukemia
por: Gao, Yanan, et al.
Publicado: (2016)

Development and characterization of a DNA aptamer for MLL-AF9 expressing acute myeloid leukemia cells using whole cell-SELEX
por: Earnest, Kaylin G., et al.
Publicado: (2021)

PB1805: BREAKING A PARADIGM: LOSS OF STAT3 INCREASES INVASION IN MLL-AF9-DRIVEN ACUTE MYELOID LEUKEMIA
por: Zdársky, Bernhard, et al.
Publicado: (2023)

RNAi-mediated silencing of MLL-AF9 reveals leukemia-associated downstream targets and processes
por: Fleischmann, Katrin K, et al.
Publicado: (2014)

Smyd2 is a Myc-regulated gene critical for MLL-AF9 induced leukemogenesis
por: Bagislar, Sevgi, et al.
Publicado: (2016)

HSF1 is a driver of leukemia stem cell self-renewal in acute myeloid leukemia
por: Dong, Qianze, et al.
Publicado: (2022)

Higher expression levels of the HOXA9 gene, closely associated with MLL-PTD and EZH2 mutations, predict inferior outcome in acute myeloid leukemia
por: Gao, Li, et al.
Publicado: (2016)

ZNF521 Enhances MLL-AF9-Dependent Hematopoietic Stem Cell Transformation in Acute Myeloid Leukemias by Altering the Gene Expression Landscape †
por: Chiarella, Emanuela, et al.
Publicado: (2021)

CXCR4 Signaling Has a CXCL12-Independent Essential Role in Murine MLL-AF9-Driven Acute Myeloid Leukemia
por: Ramakrishnan, Ramprasad, et al.
Publicado: (2020)

HoxA9 regulated Bcl-2 expression mediates survival of myeloid progenitors and the severity of HoxA9-dependent leukemia
por: Brumatti, Gabriela, et al.
Publicado: (2013)

Hematopoietic Stem Cell (HSC)-Independent Progenitors Are Susceptible to Mll-Af9-Induced Leukemic Transformation
por: Barone, Cristiana, et al.
Publicado: (2023)

Expression of MLL-AF4 or AF4-MLL fusions does not impact the efficiency of DNA damage repair
por: Castaño, Julio, et al.
Publicado: (2016)

MOZ is critical for the development of MOZ/MLL fusion–induced leukemia through regulation of Hoxa9/Meis1 expression
por: Katsumoto, Takuo, et al.
Publicado: (2022)

Transformation from acute promyelocytic leukemia in pregnancy to acute myeloid leukemia with MLL-AF9 fusion gene: A case report and literature review
por: Gao, Yang, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_itqk9aji9sdg0crr16v8m3icfu