Loss of muscleblind splicing factor shortens Caenorhabditis elegans lifespan by reducing the activity of p38 MAPK/PMK-1 and transcription factors ATF-7 and Nrf/SKN-1

Muscleblind-like splicing regulators (MBNLs) are RNA-binding factors that have an important role in developmental processes. Dysfunction of these factors is a key contributor of different neuromuscular degenerative disorders, including Myotonic Dystrophy type 1 (DM1). Since DM1 is a multisystemic di...

Descripción completa

Detalles Bibliográficos
Autores principales: Matilainen, Olli, Ribeiro, Ana R S, Verbeeren, Jens, Cetinbas, Murat, Sood, Heini, Sadreyev, Ruslan I, Garcia, Susana M D A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8633093/
https://www.ncbi.nlm.nih.gov/pubmed/34849877
http://dx.doi.org/10.1093/genetics/iyab114

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8633093/
https://www.ncbi.nlm.nih.gov/pubmed/34849877
http://dx.doi.org/10.1093/genetics/iyab114

Ejemplares similares