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Ensemble epistasis: thermodynamic origins of nonadditivity between mutations
Epistasis—when mutations combine nonadditively—is a profoundly important aspect of biology. It is often difficult to understand its mechanistic origins. Here, we show that epistasis can arise from the thermodynamic ensemble, or the set of interchanging conformations a protein adopts. Ensemble epista...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8633102/ https://www.ncbi.nlm.nih.gov/pubmed/34849909 http://dx.doi.org/10.1093/genetics/iyab105 |