Binding of the kringle‐2 domain of human plasminogen to streptococcal PAM‐type M‐protein causes dissociation of PAM dimers

The direct binding of human plasminogen (hPg), via its kringle‐2 domain (K2(hPg)), to streptococcal M‐protein (PAM), largely contributes to the pathogenesis of Pattern D Group A Streptococcus pyogenes (GAS). However, the mechanism of complex formation is unknown. In a system consisting of a Class II...

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Detalles Bibliográficos
Autores principales: Ayinuola, Olawole, Ayinuola, Yetunde A., Qiu, Cunjia, Lee, Shaun W., Ploplis, Victoria A., Castellino, Francis J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8633249/
https://www.ncbi.nlm.nih.gov/pubmed/34964287
http://dx.doi.org/10.1002/mbo3.1252

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8633249/
https://www.ncbi.nlm.nih.gov/pubmed/34964287
http://dx.doi.org/10.1002/mbo3.1252

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