Structural exploration with AlphaFold2-generated STAT3α structure reveals selective elements in STAT3α-GRIM-19 interactions involved in negative regulation

STAT3, an important transcription factor constitutively activated in cancers, is bound specifically by GRIM-19 and this interaction inhibits STAT3-dependent gene expression. GRIM-19 is therefore, considered as an inhibitor of STAT3 and may be an effective anti-cancer therapeutic target. While STAT3...

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Detalles Bibliográficos
Autores principales: Mishra, Seema, Kumar, Santosh, Choudhuri, Kesaban Sankar Roy, Longkumer, Imliyangla, Koyyada, Praveena, Kharsyiemiong, Euphinia Tiberius
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8633360/
https://www.ncbi.nlm.nih.gov/pubmed/34848745
http://dx.doi.org/10.1038/s41598-021-01436-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8633360/
https://www.ncbi.nlm.nih.gov/pubmed/34848745
http://dx.doi.org/10.1038/s41598-021-01436-7

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