The GPCR–β-arrestin complex allosterically activates C-Raf by binding its amino terminus

G protein–coupled receptors (GPCRs) convert external stimuli into cellular signals through heterotrimeric guanine nucleotide-binding proteins (G-proteins) and β-arrestins (βarrs). In a βarr-dependent signaling pathway, βarrs link GPCRs to various downstream signaling partners, such as the Raf–mitoge...

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Detalles Bibliográficos
Autores principales: Zang, Yunxiang, Kahsai, Alem W., Pakharukova, Natalia, Huang, Li-yin, Lefkowitz, Robert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Accelerated Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8633562/
https://www.ncbi.nlm.nih.gov/pubmed/34757127
http://dx.doi.org/10.1016/j.jbc.2021.101369

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8633562/
https://www.ncbi.nlm.nih.gov/pubmed/34757127
http://dx.doi.org/10.1016/j.jbc.2021.101369

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