Histone H3 lysine-trimethylation markers are decreased by recombinant methioninase and increased by methotrexate at concentrations which inhibit methionine-addicted osteosarcoma cell proliferation

Methionine addiction is a fundamental and general hallmark of cancer cells, which require exogenous methionine, despite their ability to synthesize normal amounts of methionine from homocysteine. In contrast, methionine-independent normal cells do not require exogenous methionine in the presence of...

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Detalles Bibliográficos
Autores principales: Aoki, Yusuke, Tome, Yasunori, Han, Qinghong, Yamamoto, Jun, Hamada, Kazuyuki, Masaki, Noriyuki, Bouvet, Michael, Nishida, Kotaro, Hoffman, Robert M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8633566/
https://www.ncbi.nlm.nih.gov/pubmed/34877414
http://dx.doi.org/10.1016/j.bbrep.2021.101177

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8633566/
https://www.ncbi.nlm.nih.gov/pubmed/34877414
http://dx.doi.org/10.1016/j.bbrep.2021.101177

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