Patient mutations in human ATP:cob(I)alamin adenosyltransferase differentially affect its catalytic versus chaperone functions

Human ATP:cob(I)alamin adenosyltransferase (ATR) is a mitochondrial enzyme that catalyzes an adenosyl transfer to cob(I)alamin, synthesizing 5′-deoxyadenosylcobalamin (AdoCbl) or coenzyme B(12). ATR is also a chaperone that escorts AdoCbl, transferring it to methylmalonyl-CoA mutase, which is import...

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Detalles Bibliográficos
Autores principales: Gouda, Harsha, Mascarenhas, Romila, Pillay, Shubhadra, Ruetz, Markus, Koutmos, Markos, Banerjee, Ruma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8633584/
https://www.ncbi.nlm.nih.gov/pubmed/34757128
http://dx.doi.org/10.1016/j.jbc.2021.101373

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8633584/
https://www.ncbi.nlm.nih.gov/pubmed/34757128
http://dx.doi.org/10.1016/j.jbc.2021.101373

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