Hairy and enhancer of split 1 is a primary effector of NOTCH2 signaling and induces osteoclast differentiation and function

Notch2(tm1.1Ecan) mice, which harbor a mutation replicating that found in Hajdu–Cheney syndrome, exhibit marked osteopenia because of increased osteoclast number and bone resorption. Hairy and enhancer of split 1 (HES1) is a Notch target gene and a transcriptional modulator that determines osteoclas...

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Detalles Bibliográficos
Autores principales: Yu, Jungeun, Schilling, Lauren, Eller, Tabitha, Canalis, Ernesto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8633688/
https://www.ncbi.nlm.nih.gov/pubmed/34742737
http://dx.doi.org/10.1016/j.jbc.2021.101376

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8633688/
https://www.ncbi.nlm.nih.gov/pubmed/34742737
http://dx.doi.org/10.1016/j.jbc.2021.101376

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