CRISPR-Cas9 Mediated Exonic Disruption for HIV-1 Elimination

BACKGROUND: A barrier to HIV-1 cure rests in the persistence of proviral DNA in infected CD4+ leukocytes. The high HIV-1 mutation rate leads to viral diversity, immune evasion, and consequent antiretroviral drug resistance. While CRISPR-spCas9 can eliminate latent proviral DNA, its efficacy is limit...

Descripción completa

Detalles Bibliográficos
Autores principales: Herskovitz, Jonathan, Hasan, Mahmudul, Patel, Milankumar, Blomberg, Wilson R., Cohen, Jacob D., Machhi, Jatin, Shahjin, Farah, Mosley, R. Lee, McMillan, JoEllyn, Kevadiya, Bhavesh D., Gendelman, Howard E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8633974/
https://www.ncbi.nlm.nih.gov/pubmed/34774454
http://dx.doi.org/10.1016/j.ebiom.2021.103678

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8633974/
https://www.ncbi.nlm.nih.gov/pubmed/34774454
http://dx.doi.org/10.1016/j.ebiom.2021.103678

Ejemplares similares