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CRISPR-Cas9 Mediated Exonic Disruption for HIV-1 Elimination

BACKGROUND: A barrier to HIV-1 cure rests in the persistence of proviral DNA in infected CD4+ leukocytes. The high HIV-1 mutation rate leads to viral diversity, immune evasion, and consequent antiretroviral drug resistance. While CRISPR-spCas9 can eliminate latent proviral DNA, its efficacy is limit...

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Detalles Bibliográficos
Autores principales:	Herskovitz, Jonathan, Hasan, Mahmudul, Patel, Milankumar, Blomberg, Wilson R., Cohen, Jacob D., Machhi, Jatin, Shahjin, Farah, Mosley, R. Lee, McMillan, JoEllyn, Kevadiya, Bhavesh D., Gendelman, Howard E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8633974/ https://www.ncbi.nlm.nih.gov/pubmed/34774454 http://dx.doi.org/10.1016/j.ebiom.2021.103678

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