Integrated stress response regulates GDF15 secretion from adipocytes, preferentially suppresses appetite for a high-fat diet and improves obesity

The eIF2α phosphorylation-dependent integrated stress response (ISR) is a signaling pathway that maintains homeostasis in mammalian cells exposed to various stresses. Here, ISR activation in adipocytes improves obesity and diabetes by regulating appetite in a non-cell-autonomous manner. Adipocyte-sp...

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Detalles Bibliográficos
Autores principales: Miyake, Masato, Zhang, Jun, Yasue, Akihiro, Hisanaga, Satoshi, Tsugawa, Kazue, Sakaue, Hiroshi, Oyadomari, Miho, Kiyonari, Hiroshi, Oyadomari, Seiichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8633987/
https://www.ncbi.nlm.nih.gov/pubmed/34877504
http://dx.doi.org/10.1016/j.isci.2021.103448

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8633987/
https://www.ncbi.nlm.nih.gov/pubmed/34877504
http://dx.doi.org/10.1016/j.isci.2021.103448

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