Dimethyl fumarate treatment restrains the antioxidative capacity of T cells to control autoimmunity

Dimethyl fumarate, an approved treatment for relapsing-remitting multiple sclerosis, exerts pleiotropic effects on immune cells as well as CNS resident cells. Here, we show that dimethyl fumarate exerts a profound alteration of the metabolic profile of human CD4(+) as well as CD8(+) T cells and rest...

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Detalles Bibliográficos
Autores principales: Liebmann, Marie, Korn, Lisanne, Janoschka, Claudia, Albrecht, Stefanie, Lauks, Sarah, Herrmann, Alexander M, Schulte-Mecklenbeck, Andreas, Schwab, Nicholas, Schneider-Hohendorf, Tilman, Eveslage, Maria, Wildemann, Brigitte, Luessi, Felix, Schmidt, Stephan, Diebold, Martin, Bittner, Stefan, Gross, Catharina C, Kovac, Stjepana, Zipp, Frauke, Derfuss, Tobias, Kuhlmann, Tanja, König, Simone, Meuth, Sven G, Wiendl, Heinz, Klotz, Luisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8634070/
https://www.ncbi.nlm.nih.gov/pubmed/34849598
http://dx.doi.org/10.1093/brain/awab307

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8634070/
https://www.ncbi.nlm.nih.gov/pubmed/34849598
http://dx.doi.org/10.1093/brain/awab307

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