Cargando…

Sex modifies APOE ε4 dose effect on brain tau deposition in cognitively impaired individuals

Recent studies in cognitively unimpaired elderly individuals suggest that the APOE ε4 allele exerts a dosage-dependent effect on brain tau deposition. The aim of this study was to investigate sex differences in APOE ε4 gene dosage effects on brain tau deposition in cognitively impaired individuals u...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yan, Shaozhen, Zheng, Chaojie, Paranjpe, Manish D, Li, Yanxiao, Li, Weihua, Wang, Xiuying, Benzinger, Tammie L S, Lu, Jie, Zhou, Yun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8634082/ https://www.ncbi.nlm.nih.gov/pubmed/33876815 http://dx.doi.org/10.1093/brain/awab160

Ejemplares similares

Association of sex and APOE ε4 with brain tau deposition and atrophy in older adults with Alzheimer's disease
por: Yan, Shaozhen, et al.
Publicado: (2020)

Sex modulates the ApoE ε4 effect on brain tau deposition measured by (18)F-AV-1451 PET in individuals with mild cognitive impairment
por: Liu, Min, et al.
Publicado: (2019)

The effect of ApoE ε4 on longitudinal brain region-specific glucose metabolism in patients with mild cognitive impairment: a FDG-PET study
por: Paranjpe, Manish D., et al.
Publicado: (2019)

Differential associations of APOE-ε2 and APOE-ε4 alleles with PET-measured amyloid-β and tau deposition in older individuals without dementia
por: Salvadó, Gemma, et al.
Publicado: (2021)

Effect of APOE ε4 genotype on amyloid‐β, glucose metabolism, and gray matter volume in cognitively normal individuals and amnestic mild cognitive impairment
por: Li, Weihua, et al.
Publicado: (2022)

Sex and APOE ε4 genotype modify the Alzheimer’s disease serum metabolome
por: Arnold, Matthias, et al.
Publicado: (2020)

APOE ε2 is associated with increased tau pathology in primary tauopathy
por: Zhao, Na, et al.
Publicado: (2018)

Interactive rather than independent effect of APOE and sex potentiates tau deposition in women
por: Wang, Yi-Ting T, et al.
Publicado: (2021)

APOE-ε4 synergizes with sleep disruption to accelerate Aβ deposition and Aβ-associated tau seeding and spreading
por: Wang, Chanung, et al.
Publicado: (2023)

Sex and APOE: A memory advantage in male APOE ε4 carriers in midlife
por: Zokaei, Nahid, et al.
Publicado: (2017)

APOEε4 potentiates the relationship between amyloid-β and tau pathologies
por: Therriault, Joseph, et al.
Publicado: (2020)

Tracer‐specific reference tissues selection improves detection of (18)F‐FDG, (18)F‐florbetapir, and (18)F‐flortaucipir PET SUVR changes in Alzheimer's disease
por: Li, Yanxiao, et al.
Publicado: (2022)

Sex, ApoE4 and Alzheimer’s disease: rethinking drug discovery in the era of precision medicine
por: Paranjpe, Manish D., et al.
Publicado: (2021)

The ε3 and ε4 Alleles of Human APOE Differentially Affect Tau Phosphorylation in Hyperinsulinemic and Pioglitazone Treated Mice
por: To, Alvina W. M., et al.
Publicado: (2011)

Frequency of Biologically Defined Alzheimer Disease in Relation to Age, Sex, APOE ε4, and Cognitive Impairment
por: Therriault, Joseph, et al.
Publicado: (2021)

Association of APOE Serum Levels and APOE ε2, ε3, and ε4 Alleles with Optic Neuritis
por: Momkute, Liucija, et al.
Publicado: (2022)

Effect of APOE ε4 genotype on amyloid-β and tau accumulation in Alzheimer’s disease
por: Baek, Min Seok, et al.
Publicado: (2020)

Amyloid pathology but not APOE ε4 status is permissive for tau-related hippocampal dysfunction
por: Düzel, Emrah, et al.
Publicado: (2022)

The Relationship Between Hippocampal Volumes and Delayed Recall Is Modified by APOE ε4 in Mild Cognitive Impairment
por: Wang, Xiwu, et al.
Publicado: (2019)

Spatial patterns of tau deposition are associated with amyloid, ApoE, sex, and cognitive decline in older adults
por: Pereira, Joana B., et al.
Publicado: (2020)

APOEε4 associates with microglial activation independently of Aβ plaques and tau tangles
por: Ferrari-Souza, João Pedro, et al.
Publicado: (2023)

The Relationship of APOE ε4, Race, and Sex on the Age of Onset and Risk of Dementia
por: Powell, Danielle S., et al.
Publicado: (2021)

APOE ϵ4 modifies the relationship between infectious burden and poor cognition
por: Zhao, Chen, et al.
Publicado: (2020)

The relationship between complement factor C3, APOE ε4, amyloid and tau in Alzheimer’s disease
por: Bonham, Luke W., et al.
Publicado: (2016)

Sex and APOE ɛ4 modify the effect of cardiovascular risk on tau in cognitively normal older adults
por: Tsiknia, Amaryllis A., et al.
Publicado: (2022)

Effects of age, amyloid, sex, and APOE ε4 on the CSF proteome in normal cognition
por: Wesenhagen, Kirsten E.J., et al.
Publicado: (2022)

Effects of APOE ε2 allele on basal forebrain functional connectivity in mild cognitive impairment
por: Liu, Xiaocao, et al.
Publicado: (2022)

Identification of epigenome-wide DNA methylation differences between carriers of APOE ε4 and APOE ε2 alleles
por: Walker, Rosie M., et al.
Publicado: (2021)

Astrocytic function is associated with both amyloid-β and tau pathology in non-demented APOE ϵ4 carriers
por: Spotorno, Nicola, et al.
Publicado: (2022)

The Effect of the APOE-ε4 Allele on the Cholinergic Circuitry for Subjects With Different Levels of Cognitive Impairment
por: Lai, Ying-Liang Larry, et al.
Publicado: (2021)

Association of Pancreatic Polypeptide with Mild Cognitive Impairment Varies by APOE ε4 Allele
por: Roberts, Rosebud O., et al.
Publicado: (2015)

Sex-specific BDNF and APOE ε4 genotype interactions on white matter hyperintensity volume
por: Pitts, Brandon
Publicado: (2020)

Inverse Association of APOE ε4 and Glaucoma Modified by Systemic Hypertension: The Canadian Longitudinal Study on Aging
por: Freeman, Ellen E., et al.
Publicado: (2022)

Association of APOE ε4/ε4 with fluid biomarkers in patients from the PUMCH dementia cohort
por: Shang, Li, et al.
Publicado: (2023)

Greater tau load and reduced cortical thickness in APOE ε4-negative Alzheimer’s disease: a cohort study
por: Mattsson, Niklas, et al.
Publicado: (2018)

Polygenic score modifies risk for Alzheimer's disease in APOE ε4 homozygotes at phenotypic extremes
por: Huq, Aamira J., et al.
Publicado: (2021)

Bilateral Implantation of Shear Stress Modifier in ApoE Knockout Mouse Induces Cognitive Impairment and Tau Abnormalities
por: Nie, Shuke, et al.
Publicado: (2018)

APOE Promoter Polymorphism-219T/G is an Effect Modifier of the Influence of APOE ε4 on Alzheimer’s Disease Risk in a Multiracial Sample
por: Choi, Kyu Yeong, et al.
Publicado: (2019)

Subjective cognitive decline, APOE ε4, and incident mild cognitive impairment in men and women
por: Müller-Gerards, Diana, et al.
Publicado: (2019)

Dissecting the Gene Dose-Effects of the APOE ε4 and ε2 Alleles on Hippocampal Volumes in Aging and Alzheimer’s Disease
por: Hostage, Christopher A., et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_ndhmb97l3aqirkv42a1art9r2g