N-Acetyl Cysteine Restores Sirtuin-6 and Decreases HMGB1 Release Following Lipopolysaccharide-Sensitized Hypoxic-Ischemic Brain Injury in Neonatal Mice

Inflammation and neonatal hypoxia-ischemia (HI) are important etiological factors of perinatal brain injury. However, underlying mechanisms remain unclear. Sirtuins are a family of nicotinamide adenine dinucleotide (NAD)+-dependent histone deacetylases. Sirtuin-6 is thought to regulate inflammatory...

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Detalles Bibliográficos
Autores principales: Singh-Mallah, Gagandeep, Kawamura, Takuya, Ardalan, Maryam, Chumak, Tetyana, Svedin, Pernilla, Arthur, Peter G., James, Christopher, Hagberg, Henrik, Sandberg, Mats, Mallard, Carina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cellular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8634142/
https://www.ncbi.nlm.nih.gov/pubmed/34867200
http://dx.doi.org/10.3389/fncel.2021.743093

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8634142/
https://www.ncbi.nlm.nih.gov/pubmed/34867200
http://dx.doi.org/10.3389/fncel.2021.743093

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