From the Design to the In Vivo Evaluation of Benzohomoadamantane-Derived Soluble Epoxide Hydrolase Inhibitors for the Treatment of Acute Pancreatitis

[Image: see text] The pharmacological inhibition of soluble epoxide hydrolase (sEH) is efficient for the treatment of inflammatory and pain-related diseases. Numerous potent sEH inhibitors (sEHIs) present adamantyl or phenyl moieties, such as the clinical candidates AR9281 or EC5026. Herein, in a ne...

Descripción completa

Detalles Bibliográficos
Autores principales: Codony, Sandra, Calvó-Tusell, Carla, Valverde, Elena, Osuna, Sílvia, Morisseau, Christophe, Loza, M. Isabel, Brea, José, Pérez, Concepción, Rodríguez-Franco, María Isabel, Pizarro-Delgado, Javier, Corpas, Rubén, Griñán-Ferré, Christian, Pallàs, Mercè, Sanfeliu, Coral, Vázquez-Carrera, Manuel, Hammock, Bruce D., Feixas, Ferran, Vázquez, Santiago
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8634379/
https://www.ncbi.nlm.nih.gov/pubmed/33945278
http://dx.doi.org/10.1021/acs.jmedchem.0c01601

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8634379/
https://www.ncbi.nlm.nih.gov/pubmed/33945278
http://dx.doi.org/10.1021/acs.jmedchem.0c01601

Ejemplares similares