Pilot Study Assessing the Impact of Intrathecal Administration of Variants AAV-PHP.B and AAV-PHP.eB on Brain Transduction in Adult Rhesus Macaques

Adeno-associated virus (AAV) vectors are increasingly used as an effective and safe approach to deliver genetic material to the central nervous system (CNS). The AAV9-derived variants, AAV-PHP. B and AAV-PHP.eB, reportedly broadly transduce cells throughout the CNS compared to the original serotype...

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Detalles Bibliográficos
Autores principales: Arotcarena, Marie-Laure, Dovero, Sandra, Biendon, Nathalie, Dutheil, Nathalie, Planche, Vincent, Bezard, Erwan, Dehay, Benjamin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Bioengineering and Biotechnology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8634843/
https://www.ncbi.nlm.nih.gov/pubmed/34869273
http://dx.doi.org/10.3389/fbioe.2021.762209

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8634843/
https://www.ncbi.nlm.nih.gov/pubmed/34869273
http://dx.doi.org/10.3389/fbioe.2021.762209

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