Sustained AMPK Activation and Proline Metabolism Play Critical Roles in the Survival of Matrix-Deprived Transformed Cells

Attachment to the matrix is critical for the survival of adherent cells, whereas detachment triggers death by apoptosis. Therefore, solid tumors must acquire the ability to survive the stress of matrix-detachment to transit through circulation and seed metastases. Although a central role for energy...

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Detalles Bibliográficos
Autores principales: Saha, Manipa, Deshpande, Neha, Dubey, Abhinav, Pal, Debnath, Atreya, Hanudatta S., Rangarajan, Annapoorni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8634847/
https://www.ncbi.nlm.nih.gov/pubmed/34869367
http://dx.doi.org/10.3389/fcell.2021.771366

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8634847/
https://www.ncbi.nlm.nih.gov/pubmed/34869367
http://dx.doi.org/10.3389/fcell.2021.771366

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