Design, Synthesis, and Biological Evaluation of Pyrano[2,3-c]-pyrazole–Based RalA Inhibitors Against Hepatocellular Carcinoma

The activation of Ras small GTPases, including RalA and RalB, plays an important role in carcinogenesis, tumor progress, and metastasis. In the current study, we report the discovery of a series of 6-sulfonylamide-pyrano [2,3-c]-pyrazole derivatives as novel RalA inhibitors. ELISA-based biochemical...

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Detalles Bibliográficos
Autores principales: Wang, Yuting, He, Mingyao, Li, Xiang, Chai, Jinlong, Jiang, Qinglin, Peng, Cheng, He, Gu, Huang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8634879/
https://www.ncbi.nlm.nih.gov/pubmed/34869198
http://dx.doi.org/10.3389/fchem.2021.700956

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8634879/
https://www.ncbi.nlm.nih.gov/pubmed/34869198
http://dx.doi.org/10.3389/fchem.2021.700956

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