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Reversion Mosaicism in Primary Immunodeficiency Diseases

Reversion mosaicism has been reported in an increasing number of genetic disorders including primary immunodeficiency diseases. Several mechanisms can mediate somatic reversion of inherited mutations. Back mutations restore wild-type sequences, whereas second-site mutations result in compensatory ch...

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Detalles Bibliográficos
Autores principales: Miyazawa, Hanae, Wada, Taizo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8635092/
https://www.ncbi.nlm.nih.gov/pubmed/34868061
http://dx.doi.org/10.3389/fimmu.2021.783022