Epigenetic Modulation of Class-Switch DNA Recombination to IgA by miR-146a Through Downregulation of Smad2, Smad3 and Smad4

IgA is the predominant antibody isotype at intestinal mucosae, where it plays a critical role in homeostasis and provides a first line of immune protection. Dysregulation of IgA production, however, can contribute to immunopathology, particularly in kidneys in which IgA deposition can cause nephropa...

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Detalles Bibliográficos
Autores principales: Casali, Paolo, Li, Shili, Morales, Grecia, Daw, Cassidy C., Chupp, Daniel P., Fisher, Amanda D., Zan, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8635144/
https://www.ncbi.nlm.nih.gov/pubmed/34868004
http://dx.doi.org/10.3389/fimmu.2021.761450

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8635144/
https://www.ncbi.nlm.nih.gov/pubmed/34868004
http://dx.doi.org/10.3389/fimmu.2021.761450

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