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Illumination of serotonin transporter mechanism and role of the allosteric site

The serotonin transporter (SERT) terminates serotonin signaling by using sodium and chloride gradients to drive reuptake of serotonin into presynaptic neurons and is the target of widely used medications to treat neuropsychiatric disorders. Despite decades of study, the molecular mechanism of seroto...

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Detalles Bibliográficos
Autores principales: Yang, Dongxue, Gouaux, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8635421/
https://www.ncbi.nlm.nih.gov/pubmed/34851672
http://dx.doi.org/10.1126/sciadv.abl3857