De novo macrocyclic peptides for inhibiting, stabilizing, and probing the function of the retromer endosomal trafficking complex

The retromer complex (Vps35-Vps26-Vps29) is essential for endosomal membrane trafficking and signaling. Mutation of the retromer subunit Vps35 causes late-onset Parkinson’s disease, while viral and bacterial pathogens can hijack the complex during cellular infection. To modulate and probe its functi...

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Detalles Bibliográficos
Autores principales: Chen, Kai-En, Guo, Qian, Hill, Timothy A., Cui, Yi, Kendall, Amy K., Yang, Zhe, Hall, Ryan J., Healy, Michael D., Sacharz, Joanna, Norwood, Suzanne J., Fonseka, Sachini, Xie, Boyang, Reid, Robert C., Leneva, Natalya, Parton, Robert G., Ghai, Rajesh, Stroud, David A., Fairlie, David P., Suga, Hiroaki, Jackson, Lauren P., Teasdale, Rohan D., Passioura, Toby, Collins, Brett M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8635440/
https://www.ncbi.nlm.nih.gov/pubmed/34851660
http://dx.doi.org/10.1126/sciadv.abg4007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8635440/
https://www.ncbi.nlm.nih.gov/pubmed/34851660
http://dx.doi.org/10.1126/sciadv.abg4007

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