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Reduced preload increases Mechanical Control (strain-rate dependence) of Relaxation by modifying myosin kinetics
Rapid myocardial relaxation is essential in maintaining cardiac output, and impaired relaxation is an early indicator of diastolic dysfunction. While the biochemical modifiers of relaxation are well known to include calcium handling, thin filament activation, and myosin kinetics, biophysical and bio...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8635462/ https://www.ncbi.nlm.nih.gov/pubmed/34015323 http://dx.doi.org/10.1016/j.abb.2021.108909 |