Eplerenone nanocrystals engineered by controlled crystallization for enhanced oral bioavailability

Poor aqueous solubility of eplerenone (EPL) is a major obstacle to achieve sufficient bioavailability after oral administration. In this study, we aimed to develop and evaluate eplerenone nanocrystals (EPL-NCs) for solubility and dissolution enhancement. D-optimal combined mixture process using Desi...

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Detalles Bibliográficos
Autores principales: Khan, Muhammad Ayub, Ansari, Muhammad Mohsin, Arif, Sadia Tabassam, Raza, Abida, Choi, Ho-Ik, Lim, Chang-Wan, Noh, Ha-Yeon, Noh, Jin-Su, Akram, Salman, Nawaz, Hafiz Awais, Ammad, Muhammad, Alamro, Abir Abdullah, Alghamdi, Amani Ahmed, Kim, Jin-Ki, Zeb, Alam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8635601/
https://www.ncbi.nlm.nih.gov/pubmed/34842018
http://dx.doi.org/10.1080/10717544.2021.2008051

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8635601/
https://www.ncbi.nlm.nih.gov/pubmed/34842018
http://dx.doi.org/10.1080/10717544.2021.2008051

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