Cargando…

Eplerenone nanocrystals engineered by controlled crystallization for enhanced oral bioavailability

Poor aqueous solubility of eplerenone (EPL) is a major obstacle to achieve sufficient bioavailability after oral administration. In this study, we aimed to develop and evaluate eplerenone nanocrystals (EPL-NCs) for solubility and dissolution enhancement. D-optimal combined mixture process using Desi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Khan, Muhammad Ayub, Ansari, Muhammad Mohsin, Arif, Sadia Tabassam, Raza, Abida, Choi, Ho-Ik, Lim, Chang-Wan, Noh, Ha-Yeon, Noh, Jin-Su, Akram, Salman, Nawaz, Hafiz Awais, Ammad, Muhammad, Alamro, Abir Abdullah, Alghamdi, Amani Ahmed, Kim, Jin-Ki, Zeb, Alam
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8635601/ https://www.ncbi.nlm.nih.gov/pubmed/34842018 http://dx.doi.org/10.1080/10717544.2021.2008051

Ejemplares similares

Augmented Oral Bioavailability and Prokinetic Activity of Levosulpiride Delivered in Nanostructured Lipid Carriers
por: Arif, Sadia Tabassam, et al.
Publicado: (2022)

Contribution of Attenuation of TNF-α and NF-κB in the Anti-Epileptic, Anti-Apoptotic and Neuroprotective Potential of Rosa webbiana Fruit and Its Chitosan Encapsulation
por: Firdous, Anum, et al.
Publicado: (2021)

Insights Into the Role of Epigenetic Factors Determining the Estrogen Response in Estrogen-Positive Ovarian Cancer and Prospects of Combining Epi-Drugs With Endocrine Therapy
por: Sarwar, Sadia, et al.
Publicado: (2022)

Enhanced Antidepressant Activity of Nanostructured Lipid Carriers Containing Levosulpiride in Behavioral Despair Tests in Mice
por: Arif, Sadia Tabassam, et al.
Publicado: (2023)

Formulation and Evaluation of a Self-Microemulsifying Drug Delivery System of Raloxifene with Improved Solubility and Oral Bioavailability
por: Ansari, Muhammad Mohsin, et al.
Publicado: (2023)

Eplerenone ethanol solvate
por: Yang, Qian, et al.
Publicado: (2008)

Formulation and Characterization of Eplerenone Nanoemulsion Liquisolids, An Oral Delivery System with Higher Release Rate and Improved Bioavailability
por: Khames, Ahmed
Publicado: (2019)

The Effect of Local Renin Angiotensin System in the Common Types of Cancer
por: Almutlaq, Moudhi, et al.
Publicado: (2021)

Enhanced Accumulation of Cisplatin in Ovarian Cancer Cells from Combination with Wedelolactone and Resulting Inhibition of Multiple Epigenetic Drivers
por: Sarwar, Sadia, et al.
Publicado: (2021)

Wireless E-Nose Sensors to Detect Volatile Organic Gases through Multivariate Analysis
por: Rahman, Saifur, et al.
Publicado: (2020)

Eplerenone in the Treatment of Polypoidal Choroidal Vasculopathy
por: Kapoor, Kapil G., et al.
Publicado: (2015)

Eplerenone: The Multifaceted Drug in Cardiovascular Pharmacology
por: Pradhan, Akshyaya, et al.
Publicado: (2020)

Stabilizing Agents for Drug Nanocrystals: Effect on Bioavailability
por: Tuomela, Annika, et al.
Publicado: (2016)

Eplerenone use in primary aldosteronism during pregnancy
por: Gunganah, Kirun, et al.
Publicado: (2015)

Eplerenone Treatment in Chronic Central Serous Chorioretinopathy
por: Iqbal, Faisal, et al.
Publicado: (2021)

A hybrid technique for speech segregation and classification using a sophisticated deep neural network
por: Qazi, Khurram Ashfaq, et al.
Publicado: (2018)

Design optimization of powered ankle prosthesis to reduce peak power requirement
por: Bilal, Muhammad, et al.
Publicado: (2022)

Metabolite Profiling of Malaysian Gracilaria edulis Reveals Eplerenone as Novel Antibacterial Compound for Drug Repurposing Against MDR Bacteria
por: Asghar, Ali, et al.
Publicado: (2021)

Effect of Eplerenone on the Glomerular Filtration Rate (GFR) in Primary Aldosteronism: Sequential Changes in the GFR During Preoperative Eplerenone Treatment to Subsequent Adrenalectomy
por: Nakano, Yujiro, et al.
Publicado: (2018)

Performance Analysis of Boosting Classifiers in Recognizing Activities of Daily Living
por: Rahman, Saifur, et al.
Publicado: (2020)

Internet of Things and cloud computing
por: Singh, Nishant, et al.
Publicado: (2021)

Efficacy and safety of eplerenone treatment for patients with diabetic nephropathy: A meta-analysis
por: Hu, Honglei, et al.
Publicado: (2022)

Efficacy and Safety of Eplerenone for Treating Chronic Kidney Disease: A Meta-Analysis
por: Hu, Honglei, et al.
Publicado: (2023)

Rationale for treating oedema in Duchenne muscular dystrophy with eplerenone
por: LEHMANN-HORN, FRANK, et al.
Publicado: (2012)

Possible dose-dependent effect of eplerenone on intraocular pressure
por: Razavi, Seyedeh Mehrsa Sadat, et al.
Publicado: (2023)

Hydroxypropylcellulose-flurbiprofen conjugates: design, characterization, anti-inflammatory activity and enhanced bioavailability
por: Hussain, Muhammad Ajaz, et al.
Publicado: (2020)

Fenofibrate Nanocrystals Embedded in Oral Strip-Films for Bioavailability Enhancement
por: Kevadiya, Bhavesh D., et al.
Publicado: (2018)

Nanocrystals of Poorly Soluble Drugs: Drug Bioavailability and Physicochemical Stability
por: Gigliobianco, Maria Rosa, et al.
Publicado: (2018)

Nanocrystalization: An Emerging Technology to Enhance the  Bioavailability of Poorly Soluble Drugs
por: Joshi, Kavita, et al.
Publicado: (2019)

The contribution of absorption of integral nanocrystals to enhancement of oral bioavailability of quercetin
por: Shen, Baode, et al.
Publicado: (2021)

Preparation and optimization of surface stabilized cryptotanshinone nanocrystals with enhanced bioavailability
por: Zhao, Wenzheng, et al.
Publicado: (2023)

Angiotensin II Exaggerates SARS-CoV-2 Specific T-Cell Response in Convalescent Individuals following COVID-19
por: Almutlaq, Moudhi, et al.
Publicado: (2022)

Novel nanocrystal-based solid dispersion with high drug loading, enhanced dissolution, and bioavailability of andrographolide
por: Ma, Yueqin, et al.
Publicado: (2018)

Dose Tailoring of Vancomycin Through Population Pharmacokinetic Modeling Among Surgical Patients in Pakistan
por: Munir, Muhammad Muaaz, et al.
Publicado: (2021)

The Influence of Ionizing Radiation, Temperature, and Light on Eplerenone in the Solid State
por: Dettlaff, Katarzyna, et al.
Publicado: (2014)

Eplerenone in the treatment of central serous chorioretinopathy: a review of the literature
por: Chatziralli, Irini, et al.
Publicado: (2018)

Lack of efficacy of eplerenone for treatment of active central serous chorioretinopathy
por: Sadda, Srinivas R.
Publicado: (2020)

Bilateral bullous central serous chorioretinopathy treated with PDT and eplerenone
por: Anderson, William J., et al.
Publicado: (2022)

Surface stabilized atorvastatin nanocrystals with improved bioavailability, safety and antihyperlipidemic potential
por: Sharma, Manu, et al.
Publicado: (2019)

Frequency and correlates of symptoms of anxiety and depression among young caregivers of cancer patients: a pilot study
por: Majeed, Muhammad Hassan, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_tn8m5r3ua5mvv2evkacrv78v0b