JAK2-STAT Epigenetically Regulates Tolerized Genes in Monocytes in the First Encounter With Gram-Negative Bacterial Endotoxins in Sepsis

Microbial challenges, such as widespread bacterial infection in sepsis, induce endotoxin tolerance, a state of hyporesponsiveness to subsequent infections. The participation of DNA methylation in this process is poorly known. In this study, we perform integrated analysis of DNA methylation and trans...

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Detalles Bibliográficos
Autores principales: Morante-Palacios, Octavio, Lorente-Sorolla, Clara, Ciudad, Laura, Calafell-Segura, Josep, Garcia-Gomez, Antonio, Català-Moll, Francesc, Ruiz-Sanmartín, Adolfo, Martínez-Gallo, Mónica, Ferrer, Ricard, Ruiz-Rodriguez, Juan Carlos, Álvarez-Errico, Damiana, Ballestar, Esteban
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8635809/
https://www.ncbi.nlm.nih.gov/pubmed/34867954
http://dx.doi.org/10.3389/fimmu.2021.734652

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8635809/
https://www.ncbi.nlm.nih.gov/pubmed/34867954
http://dx.doi.org/10.3389/fimmu.2021.734652

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