Microtubules regulate pancreatic β-cell heterogeneity via spatiotemporal control of insulin secretion hot spots

Heterogeneity of glucose-stimulated insulin secretion (GSIS) in pancreatic islets is physiologically important but poorly understood. Here, we utilize mouse islets to determine how microtubules (MTs) affect secretion toward the vascular extracellular matrix at single cell and subcellular levels. Our...

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Detalles Bibliográficos
Autores principales: Trogden, Kathryn P, Lee, Justin, Bracey, Kai M, Ho, Kung-Hsien, McKinney, Hudson, Zhu, Xiaodong, Arpag, Goker, Folland, Thomas G, Osipovich, Anna B, Magnuson, Mark A, Zanic, Marija, Gu, Guoqiang, Holmes, William R, Kaverina, Irina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8635970/
https://www.ncbi.nlm.nih.gov/pubmed/34783306
http://dx.doi.org/10.7554/eLife.59912

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8635970/
https://www.ncbi.nlm.nih.gov/pubmed/34783306
http://dx.doi.org/10.7554/eLife.59912

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