The alpha/B.1.1.7 SARS-CoV-2 variant exhibits significantly higher affinity for ACE-2 and requires lower inoculation doses to cause disease in K18-hACE2 mice

The alpha/B.1.1.7 SARS-CoV-2 lineage emerged in autumn 2020 in the United Kingdom and transmitted rapidly until winter 2021 when it was responsible for most new COVID-19 cases in many European countries. The incidence domination was likely due to a fitness advantage that could be driven by the recep...

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Detalles Bibliográficos
Autores principales: Bayarri-Olmos, Rafael, Johnsen, Laust Bruun, Idorn, Manja, Reinert, Line S, Rosbjerg, Anne, Vang, Søren, Hansen, Cecilie Bo, Helgstrand, Charlotte, Bjelke, Jais Rose, Bak-Thomsen, Theresa, Paludan, Søren R, Garred, Peter, Skjoedt, Mikkel-Ole
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8635972/
https://www.ncbi.nlm.nih.gov/pubmed/34821555
http://dx.doi.org/10.7554/eLife.70002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8635972/
https://www.ncbi.nlm.nih.gov/pubmed/34821555
http://dx.doi.org/10.7554/eLife.70002

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