IL-21 Rescues the Defect of IL-10-Producing Regulatory B Cells and Improves Allergic Asthma in DOCK8 Deficient Mice

Mutations in human DOCK8 cause a combined immunodeficiency syndrome characterized by allergic diseases such as asthma and food allergy. However, the underlying mechanism is unclear. Regulatory B (Breg) cells that produce IL-10 exert potent immunosuppressive functions in patients with allergic and au...

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Detalles Bibliográficos
Autores principales: Jiang, Jinqiu, Qin, Tao, Zhang, Liang, Liu, Qiao, Wu, Jiabin, Dai, Rongxin, Zhou, Lina, Zhao, Qin, Luo, Xiaoyan, Wang, Hua, Zhao, Xiaodong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8636116/
https://www.ncbi.nlm.nih.gov/pubmed/34867940
http://dx.doi.org/10.3389/fimmu.2021.695596

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8636116/
https://www.ncbi.nlm.nih.gov/pubmed/34867940
http://dx.doi.org/10.3389/fimmu.2021.695596

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