Reduced dose folinic acid rescue after rapid high-dose methotrexate clearance is not associated with increased toxicity in a pediatric cohort

PURPOSE: Low doses of folinic acid (FA) rescue after high-dose methotrexate (HD-MTX) have been associated with increased toxicity, whereas high doses may be related to a decreased antileukemic effect. The optimal dosage and duration of FA rescue remain controversial. This study was designed to inves...

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Detalles Bibliográficos
Autores principales: Niinimäki, Riitta, Aarnivala, Henri, Banerjee, Joanna, Pokka, Tytti, Vepsäläinen, Kaisa, Harila-Saari, Arja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8636410/
https://www.ncbi.nlm.nih.gov/pubmed/34235555
http://dx.doi.org/10.1007/s00520-021-06395-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8636410/
https://www.ncbi.nlm.nih.gov/pubmed/34235555
http://dx.doi.org/10.1007/s00520-021-06395-3

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