IκBα is required for full transcriptional induction of some NFκB-regulated genes in response to TNF in MCF-7 cells

Inflammatory stimuli triggers the degradation of three inhibitory κB (IκB) proteins, allowing for nuclear translocation of nuclear factor-κB (NFκB) for transcriptional induction of its target genes. Of these three, IκBα is a well-known negative feedback regulator that limits the duration of NFκB act...

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Detalles Bibliográficos
Autores principales: Ando, Minami, Magi, Shigeyuki, Seki, Masahide, Suzuki, Yutaka, Kasukawa, Takeya, Lefaudeux, Diane, Hoffmann, Alexander, Okada, Mariko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8636565/
https://www.ncbi.nlm.nih.gov/pubmed/34853340
http://dx.doi.org/10.1038/s41540-021-00204-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8636565/
https://www.ncbi.nlm.nih.gov/pubmed/34853340
http://dx.doi.org/10.1038/s41540-021-00204-7

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