Cargando…

ALKBH5-mediated m(6)A demethylation of KCNK15-AS1 inhibits pancreatic cancer progression via regulating KCNK15 and PTEN/AKT signaling

Long noncoding RNAs (lncRNAs) are regarded as crucial regulators in tumor progression. Potassium two pore domain channel subfamily K member 15 and WISP2 antisense RNA 1 (KCNK15-AS1) has been confirmed to inhibit the migration and invasion of pancreatic cancer (PC) cells. However, its downstream mech...

Descripción completa

Detalles Bibliográficos
Autores principales:	He, Yuan, Yue, HongQin, Cheng, Ying, Ding, Zhilong, Xu, Zhen, Lv, Chunyang, Wang, Zheng, Wang, Jing, Yin, Chenglong, Hao, Huihui, Chen, Chuang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8636648/ https://www.ncbi.nlm.nih.gov/pubmed/34853296 http://dx.doi.org/10.1038/s41419-021-04401-4

Ejemplares similares

2-Aminoethoxydiphenyl borate activates the mechanically gated human KCNK channels KCNK 2 (TREK-1), KCNK 4 (TRAAK), and KCNK 10 (TREK-2)
por: Beltrán, Leopoldo, et al.
Publicado: (2013)

Identification and characterization of two zebrafish Twik related potassium channels, Kcnk2a and Kcnk2b
por: Nasr, Nathalie, et al.
Publicado: (2018)

The correlation and role analysis of KCNK2/4/5/15 in Human Papillary Thyroid Carcinoma microenvironment
por: Lin, Xu, et al.
Publicado: (2020)

KCNK levels are prognostic and diagnostic markers for hepatocellular carcinoma
por: Li, Wen-Chao, et al.
Publicado: (2019)

Background K(2P) Channels KCNK3/9/15 Limit the Budding of Cell Membrane-derived Vesicles
por: Huang, Daniel Tsung-Ning, et al.
Publicado: (2011)

Opening and Closing of KcnkØ Potassium Leak Channels Is Tightly Regulated
por: Zilberberg, Noam, et al.
Publicado: (2000)

Functional analysis of missense variants in the TRESK (KCNK18) K(+) channel
por: Andres-Enguix, Isabelle, et al.
Publicado: (2012)

Epigenetic Dysregulation of KCNK9 Imprinting and Triple-Negative Breast Cancer
por: Skaar, David A., et al.
Publicado: (2021)

Silencing of KCNK15-AS1 inhibits lung cancer cell proliferation via upregulation of miR-202 and miR-370
por: Peng, Jun, et al.
Publicado: (2019)

Allelic chromatin structure primes imprinted expression of Kcnk9 during neurogenesis
por: Loftus, Daniel, et al.
Publicado: (2023)

eQTL of KCNK2 regionally influences the brain sulcal widening: evidence from 15,597 UK Biobank participants with neuroimaging data
por: Le Guen, Yann, et al.
Publicado: (2018)

Effects of the ventilatory stimulant, doxapram on human TASK‐3 (KCNK9, K2P9.1) channels and TASK‐1 (KCNK3, K2P3.1) channels
por: Cunningham, Kevin P., et al.
Publicado: (2019)

KCNK5 channels mostly expressed in cochlear outer sulcus cells are indispensable for hearing
por: Cazals, Yves, et al.
Publicado: (2015)

Integrative Analysis of KCNK Genes and Establishment of a Specific Prognostic Signature for Breast Cancer
por: Zou, Yutian, et al.
Publicado: (2022)

Gain-of-function mutations in KCNK3 cause a developmental disorder with sleep apnea
por: Sörmann, Janina, et al.
Publicado: (2022)

KCNK9 mediates the inhibitory effects of genistein on hepatic metastasis from colon cancer
por: Cheng, Yuan, et al.
Publicado: (2023)

Expanding the phenotypic spectrum of KCNK4: From syndromic neurodevelopmental disorder to rolandic epilepsy
por: Yan, Hong-Jun, et al.
Publicado: (2023)

Potassium Channel Protein KCNK6 Promotes Breast Cancer Cell Proliferation, Invasion, and Migration
por: Hou, Xiangchan, et al.
Publicado: (2021)

Proteomic Analysis of KCNK3 Loss of Expression Identified Dysregulated Pathways in Pulmonary Vascular Cells
por: Le Ribeuz, Hélène, et al.
Publicado: (2020)

Epigenomic Analysis Reveals the KCNK9 Potassium Channel as a Potential Therapeutic Target for Adenomyosis
por: Chu, Ling-Hui, et al.
Publicado: (2022)

Role of hippocampal circKcnk9 in visceral hypersensitivity and anxiety comorbidity of irritable bowel syndrome
por: Liu, Yuan, et al.
Publicado: (2022)

The transcription factor Foxd3 induces spinal cord ischemia-reperfusion injury by potentiating microRNA-214-dependent inhibition of Kcnk2
por: Li, Ran, et al.
Publicado: (2020)

Kcnk3, Ggta1, and Gpr84 are involved in hyperbaric oxygenation preconditioning protection on cerebral ischemia–reperfusion injury
por: Yang, Chunhui, et al.
Publicado: (2021)

Pharmacoinformatics elucidation of potential drug targets against migraine to target ion channel protein KCNK18
por: Sehgal, Sheikh Arslan, et al.
Publicado: (2014)

The Impact of Heterozygous KCNK3 Mutations Associated With Pulmonary Arterial Hypertension on Channel Function and Pharmacological Recovery
por: Bohnen, Michael S., et al.
Publicado: (2017)

KCNK3 Mutation Causes Altered Immune Function in Pulmonary Arterial Hypertension Patients and Mouse Models
por: West, James D., et al.
Publicado: (2021)

KCNK18 Biallelic Variants Associated with Intellectual Disability and Neurodevelopmental Disorders Alter TRESK Channel Activity
por: Pavinato, Lisa, et al.
Publicado: (2021)

KCNK3 inhibits proliferation and glucose metabolism of lung adenocarcinoma via activation of AMPK-TXNIP pathway
por: Lin, Guofu, et al.
Publicado: (2022)

Crosstalk between BMP signaling and KCNK3 in phenotypic switching of pulmonary vascular smooth muscle cells
por: Yeo, Yeongju, et al.
Publicado: (2022)

NGS Nominated CELA1, HSPG2, and KCNK5 as Candidate Genes for Predisposition to Balkan Endemic Nephropathy
por: Toncheva, D., et al.
Publicado: (2014)

A monoclonal antibody against KCNK9 K(+) channel extracellular domain inhibits tumour growth and metastasis
por: Sun, Han, et al.
Publicado: (2016)

A KCNK16 mutation causing TALK-1 gain of function is associated with maturity-onset diabetes of the young
por: Graff, Sarah M., et al.
Publicado: (2021)

ALKBH4-dependent demethylation of actin regulates actomyosin dynamics
por: Li, Ming-Ming, et al.
Publicado: (2013)

The Bi-Functional Paxilline Enriched in Skin Secretion of Tree Frogs (Hyla japonica) Targets the KCNK18 and BK(Ca) Channels
por: Yin, Chuanling, et al.
Publicado: (2023)

Hydroxy-α sanshool induces colonic motor activity in rat proximal colon: a possible involvement of KCNK9
por: Kubota, Kunitsugu, et al.
Publicado: (2015)

A burden of rare variants in BMPR2 and KCNK3 contributes to a risk of familial pulmonary arterial hypertension
por: Higasa, Koichiro, et al.
Publicado: (2017)

Common variants in KCNK5 and FHL5 genes contributed to the susceptibility of migraine without aura in Han Chinese population
por: Jiang, Zhao, et al.
Publicado: (2021)

Gain and loss of TASK3 channel function and its regulation by novel variation cause KCNK9 imprinting syndrome
por: Cousin, Margot A., et al.
Publicado: (2022)

Dominant-Negative Effect of a Missense Variant in the TASK-2 (KCNK5) K(+) Channel Associated with Balkan Endemic Nephropathy
por: Reed, Alan P., et al.
Publicado: (2016)

Effect of 158 herbal remedies on human TRPV1 and the two-pore domain potassium channels KCNK2, 3 and 9
por: Herbrechter, Robin, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_t1037skjca5h932d59masihp53