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Pre-steady-state Kinetic Analysis of Amino Acid Transporter SLC6A14 Reveals Rapid Turnover Rate and Substrate Translocation

SLC6A14 (solute carrier family 6 member 14) is an amino acid transporter, driven by Na(+) and Cl(−) co-transport, whose structure, function, and molecular and kinetic mechanism have not been well characterized. Its broad substrate selectivity, including neutral and cationic amino acids, differentiat...

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Detalles Bibliográficos
Autores principales: Shi, Yueyue, Wang, Jiali, Ndaru, Elias, Grewer, Christof
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8637194/
https://www.ncbi.nlm.nih.gov/pubmed/34867484
http://dx.doi.org/10.3389/fphys.2021.777050