Data of the quantification of the influence of DMSO concentration on the kinetic of interaction between TNFα and SPD304

The data presented here are related to the article entitled “New contributions to the drug profile of TNFα inhibitor SPD304: affinity, selectivity ADMET considerations” published in the European Journal of pharmacology. As DMSO is usually used as a co-solvent to dissolve low aqueous soluble small mo...

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Autores principales: Attia, Ghada, Mascret, Aïda, Zerrouki, Chouki, Fourati, Najla, Veitía, Maité Sylla-Iyarreta, Port, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Data Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8637341/
https://www.ncbi.nlm.nih.gov/pubmed/34901343
http://dx.doi.org/10.1016/j.dib.2021.107610
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author Attia, Ghada
Mascret, Aïda
Zerrouki, Chouki
Fourati, Najla
Veitía, Maité Sylla-Iyarreta
Port, Marc
author_facet Attia, Ghada
Mascret, Aïda
Zerrouki, Chouki
Fourati, Najla
Veitía, Maité Sylla-Iyarreta
Port, Marc
author_sort Attia, Ghada
collection PubMed
description The data presented here are related to the article entitled “New contributions to the drug profile of TNFα inhibitor SPD304: affinity, selectivity ADMET considerations” published in the European Journal of pharmacology. As DMSO is usually used as a co-solvent to dissolve low aqueous soluble small molecules, such as SPD304, we have investigated the influence of its concentration on the kinetic of interaction between tumor necrosis factor α (TNF-α) and its inhibitor, SPD304. The presented data, acquired using a surface acoustic wave sensor, can be used in further biological studies to compare the kinetic of interaction between proteins/small molecules in general and TNFα/inhibitors in particular. The estimated dissociation constant can be compared to other ones to statute on the degree of affinity between a protein and a given molecule.
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spelling pubmed-86373412021-12-09 Data of the quantification of the influence of DMSO concentration on the kinetic of interaction between TNFα and SPD304 Attia, Ghada Mascret, Aïda Zerrouki, Chouki Fourati, Najla Veitía, Maité Sylla-Iyarreta Port, Marc Data Brief Data Article The data presented here are related to the article entitled “New contributions to the drug profile of TNFα inhibitor SPD304: affinity, selectivity ADMET considerations” published in the European Journal of pharmacology. As DMSO is usually used as a co-solvent to dissolve low aqueous soluble small molecules, such as SPD304, we have investigated the influence of its concentration on the kinetic of interaction between tumor necrosis factor α (TNF-α) and its inhibitor, SPD304. The presented data, acquired using a surface acoustic wave sensor, can be used in further biological studies to compare the kinetic of interaction between proteins/small molecules in general and TNFα/inhibitors in particular. The estimated dissociation constant can be compared to other ones to statute on the degree of affinity between a protein and a given molecule. Elsevier 2021-11-20 /pmc/articles/PMC8637341/ /pubmed/34901343 http://dx.doi.org/10.1016/j.dib.2021.107610 Text en © 2021 The Authors. Published by Elsevier Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Data Article
Attia, Ghada
Mascret, Aïda
Zerrouki, Chouki
Fourati, Najla
Veitía, Maité Sylla-Iyarreta
Port, Marc
Data of the quantification of the influence of DMSO concentration on the kinetic of interaction between TNFα and SPD304
title Data of the quantification of the influence of DMSO concentration on the kinetic of interaction between TNFα and SPD304
title_full Data of the quantification of the influence of DMSO concentration on the kinetic of interaction between TNFα and SPD304
title_fullStr Data of the quantification of the influence of DMSO concentration on the kinetic of interaction between TNFα and SPD304
title_full_unstemmed Data of the quantification of the influence of DMSO concentration on the kinetic of interaction between TNFα and SPD304
title_short Data of the quantification of the influence of DMSO concentration on the kinetic of interaction between TNFα and SPD304
title_sort data of the quantification of the influence of dmso concentration on the kinetic of interaction between tnfα and spd304
topic Data Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8637341/
https://www.ncbi.nlm.nih.gov/pubmed/34901343
http://dx.doi.org/10.1016/j.dib.2021.107610
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