Simple, Single-Shot Phosphoproteomic Analysis of Heat-Stable Tau Identifies Age-Related Changes in pS235- and pS396-Tau Levels in Non-human Primates

Age is the most significant risk factor for Alzheimer’s disease (AD), and understanding its role in specific aspects of AD pathology will be critical for therapeutic development. Neurofibrillary tangles composed of hyperphosphorylated tau are a quintessential hallmark of AD. To study age-related cha...

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Detalles Bibliográficos
Autores principales: Leslie, Shannon N., Kanyo, Jean, Datta, Dibyadeep, Wilson, Rashaun S., Zeiss, Caroline, Duque, Alvaro, Lam, TuKiet T., Arnsten, Amy F. T., Nairn, Angus C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8637411/
https://www.ncbi.nlm.nih.gov/pubmed/34867294
http://dx.doi.org/10.3389/fnagi.2021.767322

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8637411/
https://www.ncbi.nlm.nih.gov/pubmed/34867294
http://dx.doi.org/10.3389/fnagi.2021.767322

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