Nose to brain delivery of Efavirenz nanosuspension for effective neuro AIDS therapy: in-vitro, in-vivo and pharmacokinetic assessment

Efavirenz is inhibitor of non-nucleoside reverse transcriptase enzyme; BCS class II drug. The objective of the present research was to prepare and evaluate nanosuspension of Efavirenz for the treatment of neuro-AIDS. Efavirenz is the substrate for drug resistant proteins at BBB prone to efflux and c...

Descripción completa

Detalles Bibliográficos
Autores principales: Kakad, Smita, Kshirsagar, Sanjay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8637478/
https://www.ncbi.nlm.nih.gov/pubmed/34901485
http://dx.doi.org/10.1016/j.heliyon.2021.e08368

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8637478/
https://www.ncbi.nlm.nih.gov/pubmed/34901485
http://dx.doi.org/10.1016/j.heliyon.2021.e08368

Ejemplares similares